Constraints on Regge models from perturbation theory

We study the constraints that the operator product expansion imposes on large $N_c$ inspired QCD models for current-current correlators. We focus on the constraints obtained by going beyond the leading-order parton computation. We explicitly show that, assumed a given mass spectrum: linear Regge behavior in $n$ (the principal quantum number) plus corrections in $1/n$, we can obtain the logarithmic (and constant) behavior in $n$ of the decay constants within a systematic expansion in $1/n$. Our example shows that it is possible to have different large $n$ behavior for the vector and pseudo-vector mass spectrum and yet comply with all the constraints from the operator product expansion.Comment: 14 pages, 6 figures; two references added, numerical analysis extended, main conclusions unchange

The AdS/QCD Correspondence: Still Undelivered

We consider the particle spectrum and event shapes in large N gauge theories in different regimes of the short-distance 't Hooft coupling, lambda. The mesons in the small lambda limit should have a Regge spectrum in order to agree with perturbation theory, while generically the large lambda theories with gravity duals produce spectra reminiscent of KK modes. We argue that these KK-like states are qualitatively different from QCD modes: they are deeply bound states which are sensitive to short distance interactions rather than the flux tube-like states expected in asymptotically free, confining gauge theories. In addition, we also find that the characteristic event shapes for the large lambda theories with gravity duals are close to spherical, very different from QCD-like (small lambda, small N) and Nambu-Goto-like (small lambda, large N) theories which have jets. This observation is in agreement with the conjecture of Strassler on event shapes in large 't Hooft coupling theories, which was recently proved by Hofman and Maldacena for the conformal case. This conclusion does not change even when considering soft-wall backgrounds in the gravity dual. The picture that emerges is the following: theories with small and large lambda are qualitatively different, while theories with small and large N are qualitatively similar. Thus it seems that it is the relative smallness of the 't Hooft coupling in QCD that prevents a reliable AdS/QCD correspondence from emerging, and that reproducing characteristic QCD-like behavior will require genuine stringy dynamics to be incorporated into any putative dual theory.Comment: 32 pages, 15 figures; references added, minor changes, history clarifie

Chiral perturbation theory calculation for pn -> dpipi at threshold

We investigate the reaction pn -> dpipi in the framework of Chiral Perturbation Theory. For the first time a complete calculation of the leading order contributions is presented. We identify various diagrams that are of equal importance as compared to those recognized in earlier works. The diagrams at leading order behave as expected by the power counting. Also for the first time the nucleon-nucleon interaction in the initial, intermediate and final state is included consistently and found to be very important. This study provides a theoretical basis for a controlled evaluation of the non-resonant contributions in two-pion production reactions in nucleon-nucleon collisions.Comment: 24 pages, 3 figures, 3 table

Seeking legitimacy through CSR: Institutional Pressures and Corporate Responses of Multinationals in Sri Lanka

Arguably, the corporate social responsibility (CSR) practices of multinational enterprises (MNEs) are influenced by a wide range of both internal and external factors. Perhaps most critical among the exogenous forces operating on MNEs are those exerted by state and other key institutional actors in host countries. Crucially, academic research conducted to date offers little data about how MNEs use their CSR activities to strategically manage their relationship with those actors in order to gain legitimisation advantages in host countries. This paper addresses that gap by exploring interactions between external institutional pressures and firm-level CSR activities, which take the form of community initiatives, to examine how MNEs develop their legitimacy-seeking policies and practices. In focusing on a developing country, Sri Lanka, this paper provides valuable insights into how MNEs instrumentally utilise community initiatives in a country where relationship-building with governmental and other powerful non-governmental actors can be vitally important for the long-term viability of the business. Drawing on neo-institutional theory and CSR literature, this paper examines and contributes to the embryonic but emerging debate about the instrumental and political implications of CSR. The evidence presented and discussed here reveals the extent to which, and the reasons why, MNEs engage in complex legitimacy-seeking relationships with Sri Lankan institutions

CryoSat instrument performance and ice product quality status

Over the past 20 years, satellite radar altimetry has shown its ability to revolutionise our understanding of the ocean and climate. Previously, these advances were largely limited to ice-free regions, neglecting large portions of the Polar Regions. Launched in 2010, the European Space Agency’s (ESA) polar-orbiting CryoSat satellite was specifically designed to measure changes in the thickness of polar sea ice and the elevation of the ice sheets and mountain glaciers. To reach this goal, the CryoSat products have to meet the highest performance standards, achieved through continual improvements of the associated Instrument Processing Facilities. Since April 2015, the CryoSat ice products are generated with Baseline-C, which represented a major processor upgrade. Several improvements were implemented in this new Baseline, most notably the release of freeboard data within the Level 2 products. The Baseline-C upgrade has brought significant improvements to the quality of Level-1B and Level-2 products relative to the previous Baseline-B products, which in turn is expected to have a positive impact on the scientific exploitation of CryoSat measurements over land ice and sea ice. This paper provides an overview of the CryoSat ice data quality assessment and evolutions, covering all quality control and calibration activities performed by ESA and its partners. Also discussed are the forthcoming evolutions of the processing chains and improvements anticipated in the next processing Baseline

Use of a non-homologous end-joining-deficient strain (delta-ku70) of the biocontrol fungus Trichoderma virens to investigate the function of the laccase gene lcc1 in sclerotia degradation

The aim of this study was to apply a generated Δtku70 strain with increased homologous recombination efficiency from the mycoparasitic fungus Trichoderma virens for studying the involvement of laccases in the degradation of sclerotia of plant pathogenic fungi. Inactivation of the non-homologous end-joining pathway has become a successful tool in filamentous fungi to overcome poor targeting efficiencies for genetic engineering. Here, we applied this principle to the biocontrol fungus T. virens, strain I10, by deleting its tku70 gene. This strain was subsequently used to delete the laccase gene lcc1, which we found to be expressed after interaction of T. virens with sclerotia of the plant pathogenic fungi Botrytis cinerea and Sclerotinia sclerotiorum. Lcc1 was strongly upregulated at early colonization of B. cinerea sclerotia and steadily induced during colonization of S. sclerotiorum sclerotia. The Δtku70Δlcc1 mutant was altered in its ability to degrade the sclerotia of B. cinerea and S. sclerotiorum. Interestingly, while the decaying ability for B. cinerea sclerotia was significantly decreased, that to degrade S. sclerotiorum sclerotia was even enhanced, suggesting the operation of different mechanisms in the mycoparasitism of these two types of sclerotia by the laccase LCC1

What to consider when pseudohypoparathyroidism is ruled out: IPPSD and differential diagnosis

Background: Pseudohypoparathyroidism (PHP) is a rare disease whose phenotypic features are rather difficult to identify in some cases. Thus, although these patients may present with the Albright''s hereditary osteodystrophy (AHO) phenotype, which is characterized by small stature, obesity with a rounded face, subcutaneous ossifications, mental retardation and brachydactyly, its manifestations are somewhat variable. Indeed, some of them present with a complete phenotype, whereas others show only subtle manifestations. In addition, the features of the AHO phenotype are not specific to it and a similar phenotype is also commonly observed in other syndromes. Brachydactyly type E (BDE) is the most specific and objective feature of the AHO phenotype, and several genes have been associated with syndromic BDE in the past few years. Moreover, these syndromes have a skeletal and endocrinological phenotype that overlaps with AHO/PHP. In light of the above, we have developed an algorithm to aid in genetic testing of patients with clinical features of AHO but with no causative molecular defect at the GNAS locus. Starting with the feature of brachydactyly, this algorithm allows the differential diagnosis to be broadened and, with the addition of other clinical features, can guide genetic testing. Methods: We reviewed our series of patients (n = 23) with a clinical diagnosis of AHO and with brachydactyly type E or similar pattern, who were negative for GNAS anomalies, and classify them according to the diagnosis algorithm to finally propose and analyse the most probable gene(s) in each case. Results: A review of the clinical data for our series of patients, and subsequent analysis of the candidate gene(s), allowed detection of the underlying molecular defect in 12 out of 23 patients: five patients harboured a mutation in PRKAR1A, one in PDE4D, four in TRPS1 and two in PTHLH. Conclusions: This study confirmed that the screening of other genes implicated in syndromes with BDE and AHO or a similar phenotype is very helpful for establishing a correct genetic diagnosis for those patients who have been misdiagnosed with "AHO-like phenotype" with an unknown genetic cause, and also for better describing the characteristic and differential features of these less common syndromes

Molecular basis of targeted therapy in T/NKcell lymphoma/leukemia: A comprehensive genomic and immunohistochemical analysis of a panel of 33 cell lines

T and NK-cell lymphoma is a collection of aggressive disorders with unfavorable outcome, in which targeted treatments are still at a preliminary phase. To gain deeper insights into the deregulated mechanisms promoting this disease, we searched a panel of 31 representative T-cell and 2 NK-cell lymphoma/leukemia cell lines for predictive markers of response to targeted therapy. To this end, targeted sequencing was performed alongside the expression of specific biomarkers corresponding to potentially activated survival pathways. The study identified TP53, NOTCH1 and DNMT3A as the most frequently mutated genes. We also found common alterations in JAK/STAT and epigenetic pathways. Immunohistochemical analysis showed nuclear accumulation of MYC (in 85% of the cases), NFKB (62%), p-STAT (44%) and p-MAPK (30%). This panel of cell lines captures the complexity of T/NK-cell lymphoproliferative processes samples, with the partial exception of AITL cases. Integrated mutational and immunohistochemical analysis shows that mutational changes cannot fully explain the activation of key survival pathways and the resulting phenotypes. The combined integration of mutational/expression changes forms a useful tool with which new compounds may be assayed